Detection of Tumor‐Specific Variants in CSF of Children With Brain Tumors, Including Low‐Grade and Cytology‐Negative Cases
In certain pediatric brain tumors, genetic diagnosis using cfDNA from CSF demonstrated promising potential. This approach has the potential for diagnosis in cases with negative cytology or low-grade tumors. However, several issues must be addressed before this method can achieve clinical utility, including its low sensitivity and the extended turnaround time for analysis.
Authors
- Takako Yoshioka (ORCID: https://orcid.org/0000-0002-2644-1846)
- Ryota Shirai (ORCID: https://orcid.org/0000-0002-1015-3444)
- Hideki Ogiwara (ORCID: https://orcid.org/0000-0002-4152-2126)
- Kenichi Usami (ORCID: https://orcid.org/0000-0002-9460-7422)
- Keita Terashima (ORCID: https://orcid.org/0000-0002-1101-5924)
- Motohiro Kato (ORCID: https://orcid.org/0000-0001-5145-1774)
- Chikako Kiyotani
- Takanori Mizuno
Institutions
- National Center For Child Health and Development (JP)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1002/1545-5017.70069
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Center for Child Health and Development
- Japan Agency for Medical Research and Development