Rare coding variation in OCD implicates shared genes with other psychiatric disorders
In this largest study to date of rare coding variation in OCD, we confirm <i>CHD8</i> as the first genome-wide significant rare-variant risk gene, show that genes that are targets of <i>CHD8</i> can carry rare and common variant risk for OCD, and identify multiple additional genes and pathways contributing to risk. Taken together, the findings show that OCD shares substantially greater genetic overlap with neurodevelopmental conditions than with adult-onset psychiatric disorders, refining the developmental framework of OCD and informing future mechanistic and clinical research.
Authors
- Maria Niarchou (ORCID: https://orcid.org/0000-0002-8855-7393)
- Marina Natividad Avila
- Matthew Delayne Halvorson
- Joseph D. Buxbaum (ORCID: https://orcid.org/0000-0001-8898-8313)
- Kathryn Roeder (ORCID: https://orcid.org/0000-0002-8869-6254)
- Dorothy E. Grice (ORCID: https://orcid.org/0000-0002-8833-2549)
- EGOS
- Nancy Pedersen
- NORDiC
- James J. Crowley
- Seulgi Jung
- Bernie Devlin
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Pittsburgh (US)
- Karolinska Institutet (SE)
- Carnegie Mellon University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-23
- DOI
- https://doi.org/10.64898/2025.12.22.25342827
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00