Mitochondrial-Targeted HDAP2 Preserves Retinal Ganglion Cells and Increases Pressure Tolerance in DBA/2J Mice
HDAP2 preserved both RGCs and axons across a range of pressure exposures and increased tolerance to IOP. These results suggest that HDAP2 may complement pressure-lowering therapy, including for normal-tension and treatment-refractory glaucoma.
Authors
- Margaret A. MacNeil
- Alexander Birk (ORCID: https://orcid.org/0000-0002-1141-8053)
- Widnie Mentor
Institutions
- The Graduate Center, CUNY (US)
- York College, City University of New York (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1167/iovs.66.15.66
- Citations
- 1
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.71