Targeting intratumoral regulatory T cells by CD137 aptamer-shRNA chimeras

This study confirms CD137 as a target for tumor immunotherapy and introduces CD137 aptamer-shRNA chimeras as novel tools to be evaluated for their usefulness in cancer treatment.

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Publication Details

Journal
Immunotherapy Advances
Published
2025-12-12
DOI
https://doi.org/10.1093/immadv/ltaf037
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
0.00

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article

Targeting intratumoral regulatory T cells by CD137 aptamer-shRNA chimeras

Kang Yi Lee, Haiyan Liu, Herbert Schwarz, Yu Mei
Immunotherapy Advances
CAR-T cell therapy research
article

Targeting intratumoral regulatory T cells by CD137 aptamer-shRNA chimeras

Kang Yi Lee, Haiyan Liu, Herbert Schwarz, Yu Mei
article en

Abstract

This study confirms CD137 as a target for tumor immunotherapy and introduces CD137 aptamer-shRNA chimeras as novel tools to be evaluated for their usefulness in cancer treatment.

Immunotherapy AdvancesVol. 6(1)
National University of Singapore (SG)
National Research Foundation
Good health and well-being
Openalex Percentile: Top 32%
CAR-T cell therapy research
DOIOpen Access PDFOpenAlex
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Targeting intratumoral regulatory T cells by CD137 aptamer-shRNA chimeras — Kang Yi Lee, Haiyan Liu, et al. · Immunotherapy Advances (2025) | TGRS Research Map | TGRS