A 64-Year-Old Woman with Fatigue and Dyspnea

AbstractMorning Report is a time-honored tradition where physicians-in-training present cases to their colleagues and clinical experts to collaboratively examine an interesting patient presentation. The Morning Report section seeks to carry on this tradition by presenting a patient's chief concern and story, inviting the reader to develop a differential diagnosis and discover the diagnosis alongside the authors of the case. This report describes the story of a 64-year-old woman with a remote history of rheumatic heart disease who presented with progressive fatigue and exertional dyspnea more than two decades after undergoing aortic- and mitral-valve replacements. Using questions, physical examination, and testing, an illness script for the presentation emerges. As the clinical course progresses, the differential is refined until a final diagnosis is made.

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Publication Details

Journal
NEJM Evidence
Published
2025-12-23
DOI
https://doi.org/10.1056/evidmr2500153
Primary Topic
Streptococcal Infections and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

A 64-Year-Old Woman with Fatigue and Dyspnea

Eric Ghiraldi, Hye Sung Kim, Shazia Nakhoda, Jennifer S. Winn
NEJM Evidence
Streptococcal Infections and Treatments
article

A 64-Year-Old Woman with Fatigue and Dyspnea

Eric Ghiraldi, Hye Sung Kim, Shazia Nakhoda, Jennifer S. Winn
article en

Abstract

AbstractMorning Report is a time-honored tradition where physicians-in-training present cases to their colleagues and clinical experts to collaboratively examine an interesting patient presentation. The Morning Report section seeks to carry on this tradition by presenting a patient's chief concern and story, inviting the reader to develop a differential diagnosis and discover the diagnosis alongside the authors of the case. This report describes the story of a 64-year-old woman with a remote history of rheumatic heart disease who presented with progressive fatigue and exertional dyspnea more than two decades after undergoing aortic- and mitral-valve replacements. Using questions, physical examination, and testing, an illness script for the presentation emerges. As the clinical course progresses, the differential is refined until a final diagnosis is made.

NEJM EvidenceVol. 5(1)
Fox Chase Cancer Center (US), Temple University Health System (US)
Gender equality
Openalex Percentile: Top 27%
Streptococcal Infections and Treatments
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A 64-Year-Old Woman with Fatigue and Dyspnea — Eric Ghiraldi, Hye Sung Kim, et al. · NEJM Evidence (2025) | TGRS Research Map | TGRS