Endoscopic findings of <i>Helicobacter pylori</i>-negative gastric mucosa-associated lymphoid tissue lymphoma

We retrospectively reviewed the endoscopic findings of Helicobacter pylori (H.pylori)-negative gastric mucosa-associated lymphoid tissue (MALT) lymphomas diagnosed over the past 10 years. The characteristic endoscopic findings of H.pylori-uninfected MALT lymphomas are small, pale, and depressed mucosal lesions that tend to be multiple. These lesions resemble undifferentiated carcinomas, and a tree-like appearance is useful for their diagnosis. Therefore, given the potential for malignancy, thorough endoscopic screening is warranted even in H. pylori-negative cases.