Depletion of Fibrinogen Suppresses Growth of Primary Tumors and Metastasis of Pancreatic Ductal Adenocarcinoma
These data suggest that fibrin(ogen) reprograms the primary tumor microenvironment to support growth and promote early, but not late, metastatic steps. Our findings support prospective evaluation of a novel clinical approach involving the integration of fibrin(ogen)-targeting or depleting agents into chemotherapy regimens to control the spread of pancreatic cancer.
Authors
- Silpa Gampala (ORCID: https://orcid.org/0000-0001-9928-3941)
- Matthew J. Flick (ORCID: https://orcid.org/0000-0002-5034-3162)
- Christian J. Kastrup (ORCID: https://orcid.org/0000-0003-3644-0019)
- Lih Jiin Juang (ORCID: https://orcid.org/0000-0003-1760-3425)
- Francesca Ferraresso
- Nayela N. Chowdhury
- Melissa L. Fishel (ORCID: https://orcid.org/0000-0002-9436-6382)
- Omar Saeed (ORCID: https://orcid.org/0000-0002-7290-2703)
- Alisa S. Wolberg (ORCID: https://orcid.org/0000-0002-2845-2303)
- Kierra Eldridge
- Jorge A. Belgodere (ORCID: https://orcid.org/0000-0003-3399-4796)
- Paul R. Territo (ORCID: https://orcid.org/0000-0003-0460-332X)
- Sha Cao
- Sae Rome Choi (ORCID: https://orcid.org/0000-0003-0975-0345)
- Kylee Brewster (ORCID: https://orcid.org/0000-0001-6988-0841)
- Kadri Kangro
- Dana K. Mitchell
- Alexey Revenko
- Bumsoo Han
- D. Wade Clapp
- Chi Zhang
- Jia Wang
- Sara Abrahams
Institutions
- University of North Carolina at Chapel Hill (US)
- Indiana University Health (US)
- University of British Columbia (CA)
- University of Illinois Urbana-Champaign (US)
- Oregon Health & Science University (US)
- Ionis Pharmaceuticals (United States) (US)
- University Medical Center New Orleans (US)
- University of Illinois Chicago (US)
- Indiana Cancer Consortium (US)
- Chan Zuckerberg Initiative (United States) (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Gastroenterology
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1053/j.gastro.2025.09.024
- Citations
- 1
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 1.52