Survival implications of the age-associated tumor and normal adjacent tissue microbiome among colorectal cancer patients

Emerging evidence has highlighted the important role of the microbiome in colorectal cancer (CRC). Since the 1990s, there has been an increase in cases of early-onset colorectal cancer. However, there is still a limited understanding of the risk factors contributing to this rise. Investigating the associations between the microbiome of tumors and normal adjacent tissue in relation to aging offers a unique perspective on potential modifiable factors. Notably, our study has shown that age-related changes in the abundance of bacteria originating from the oral cavity, such as Porphyromonas, Peptostreptococcus, and Prevotella, are linked to CRC prognosis. These findings suggest that changes in the tissue microbiome with age may serve as prognostic markers for CRC and could help inform future prevention strategies that consider dietary and oral health interventions.

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Publication Details

Journal
Gut Pathogens
Published
2025-12-23
DOI
https://doi.org/10.1186/s13099-025-00773-6
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00

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article

Survival implications of the age-associated tumor and normal adjacent tissue microbiome among colorectal cancer patients

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Gut Pathogens
Gut microbiota and health
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Survival implications of the age-associated tumor and normal adjacent tissue microbiome among colorectal cancer patients

Daniel Jeong, Ivana Radosavljevic, Erin M. Siegel, Jacob K. Kresovich, Scot E. Dowd, X. Wang, Emily Vogtmann, Rashmi R. Sinha, Stephanie Hogue, Permuth Jennifer B., Scott Pitcher, Shaneda Warren Andersen, Jessica R. Burns, Mark S. Friedman, Seth I. Felder, Amalia Stefanou, Maria F. Gomez Morales, Liang Wang, Cynthia L. Sears, Doratha A. Byrd, K. Leigh Greathouse
article en

Abstract

Emerging evidence has highlighted the important role of the microbiome in colorectal cancer (CRC). Since the 1990s, there has been an increase in cases of early-onset colorectal cancer. However, there is still a limited understanding of the risk factors contributing to this rise. Investigating the associations between the microbiome of tumors and normal adjacent tissue in relation to aging offers a unique perspective on potential modifiable factors. Notably, our study has shown that age-related changes in the abundance of bacteria originating from the oral cavity, such as Porphyromonas, Peptostreptococcus, and Prevotella, are linked to CRC prognosis. These findings suggest that changes in the tissue microbiome with age may serve as prognostic markers for CRC and could help inform future prevention strategies that consider dietary and oral health interventions.

Gut PathogensVol. 17(1)
Johns Hopkins University (US), Baylor University (US), University of South Florida (US), Moffitt Cancer Center (US), University of Wisconsin Carbone Cancer Center (US), University of Wisconsin Health (US), National Cancer Institute (US), Wisconsin Division of Public Health (US), Cellular Research (United States) (US)
Johns Hopkins University, Moffitt Cancer Center, National Cancer Institute
Good health and well-being
Openalex Percentile: Top 37%
Gut microbiota and health
DOIOpen Access PDFOpenAlex
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