Single-cell transcriptomics reveals notch regulation in quiescent LEPR⁺ endometrial mesenchymal stem cells

LEPR⁺ eMSCs represent a primitive, quiescent subset of human endometrial stem cells. Notch signaling maintains their stemness and quiescence, suggesting therapeutic relevance for endometrial regeneration.

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Publication Details

Journal
Stem Cell Research & Therapy
Published
2025-12-23
DOI
https://doi.org/10.1186/s13287-025-04803-7
Primary Topic
Reproductive System and Pregnancy
Type
article
Field-Weighted Citation Impact
0.00

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article

Single-cell transcriptomics reveals notch regulation in quiescent LEPR⁺ endometrial mesenchymal stem cells

E. Y. H. Ng, Y Fang, Cheuk-lun Lee, Pcn Chiu et al.
Stem Cell Research & Therapy
Reproductive System and Pregnancy
article

Single-cell transcriptomics reveals notch regulation in quiescent LEPR⁺ endometrial mesenchymal stem cells

E. Y. H. Ng, Y Fang, Cheuk-lun Lee, Pcn Chiu, Dandan Cao, Rachel W. S. Chan, William S. B. Yeung
article en

Abstract

LEPR⁺ eMSCs represent a primitive, quiescent subset of human endometrial stem cells. Notch signaling maintains their stemness and quiescence, suggesting therapeutic relevance for endometrial regeneration.

Stem Cell Research & TherapyVol. 16(1)
Hong Kong Polytechnic University (HK), University of Hong Kong - Shenzhen Hospital (CN), HKU-Pasteur Research Pole (HK), University of Hong Kong (HK)
Queen Mary University of London, National Natural Science Foundation of China, University of Hong Kong, University of Hong Kong-Shenzhen Hospital, Sanming Project of Medicine in Shenzhen, Basic and Applied Basic Research Foundation of Guangdong Province
Zero hunger
Openalex Percentile: Top 37%
Reproductive System and Pregnancy
DOIOpen Access PDFOpenAlex
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Single-cell transcriptomics reveals notch regulation in quiescent LEPR⁺ endometrial mesenchymal stem cells — E. Y. H. Ng, Y Fang, et al. · Stem Cell Research & Therapy (2025) | TGRS Research Map | TGRS