Sex Bias in IL-10 Production by Type I Regulatory T Cells Regulated by PI3K/mTOR Signaling
We demonstrate that sex influences IL-10 production by Tr1 cells via the PI3K pathway, potentially contributing to the greater susceptibility of women to MS. Furthermore, our data suggest that targeting PI3Kδ may represent a novel therapeutic strategy to boost IL-10 production in female pwMS.
Authors
- Florence Bucciarelli (ORCID: https://orcid.org/0000-0003-2368-9165)
- Thibault Angles
- Chanaëlle Fébrissy (ORCID: https://orcid.org/0000-0002-3819-4248)
- Anne Astier (ORCID: https://orcid.org/0000-0002-0144-3431)
- Liblau Roland
- Saniya Kari (ORCID: https://orcid.org/0009-0002-5392-0428)
- Sophie Laffont
- Aymeline Debonlier
- Françoise Lenfant
- Amelia Perez-Pestel
- Julie Guillermet-Guibert
- Shannon Elizabeth Dunn
Institutions
- Centre National de la Recherche Scientifique (FR)
- Sunnybrook Health Science Centre (CA)
- Inserm (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Centre de Recherches en Cancérologie de Toulouse (FR)
- Institut des Maladies Métaboliques et Cardiovasculaires (FR)
- Sunnybrook Hospital (CA)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1212/nxi.0000000000200532
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut National de la Santé et de la Recherche Médicale