High sensitivity measurement of circulating interferon proteins in systemic lupus erythematosus
Plasma levels of type I IFN proteins (IFNα1: IFNα13, IFNα2 and IFNω but not IFNβ) and type III IFN proteins (IFNλ1, IFNλ2:IFNλ3) were increased in active disease groups and ISG scores recapitulated this. Longitudinal intra-individual measures of these proteins are needed to explore their utility as biomarkers for SLE disease activity.
Authors
- Marie Condon (ORCID: https://orcid.org/0000-0001-7974-013X)
- Yun-Ju Huang (ORCID: https://orcid.org/0000-0002-6226-6635)
- James E. Peters (ORCID: https://orcid.org/0000-0002-9415-3440)
- Robert T. Maughan (ORCID: https://orcid.org/0000-0003-4153-903X)
- Marina Botto
- Matthew C. Pickering (ORCID: https://orcid.org/0000-0002-1153-0192)
- Thomas Cairns
- Geoffrey H.D. Leung
- Charlotte M. Bottomley
- Alex Field
- Tabitha Turner-Stokes
- Liz Lightstone
Institutions
- Imperial College Healthcare NHS Trust (GB)
- Chang Gung University (TW)
- Chang Gung Memorial Hospital (TW)
- Centre for Inflammation Research (GB)
Publication Details
- Journal
- Clinical and Experimental Rheumatology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.55563/clinexprheumatol/lyd5es
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- Imperial College London
- Imperial College Healthcare NHS Trust
- Chang Gung Medical Foundation
- NIHR Imperial Biomedical Research Centre