Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration
Our work provides evidence that VGLUT2 expression is induced in DA neurons under conditions of hypodopaminergia or D<sub>2</sub> receptor antagonism. VGLUT2 emergence in DA neurons may be a compensatory strategy when DA levels are low and/or DA receptor signalling is compromised.
Authors
- Thomas Steinkellner (ORCID: https://orcid.org/0000-0003-4591-4992)
- S SRINIVASAN
- Christian Pifl
Institutions
- Medical University of Vienna (AT)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-12-21
- DOI
- https://doi.org/10.1111/bph.70299
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Austrian Science Fund
- Universität Wien
- Medizinische Universität Wien