<i>Withania somnifera</i> root extract reduces susceptibility of the model worm <i>Caenorhabditis elegans</i> to different types of stressors
Adaptogenic potential of <i>W. somnifera</i> roots was demonstrated in worm model. WSRE can be said to possess a wide anti-stress spectrum as it protected the worms against different stressors inducing toxicity through different mechanisms including interference with acetylcholine and dopamine neurons and function. Our results support the candidature of <i>W. somnifera</i> roots as a potent nutraceutical.
Authors
- Nidhi Thakkar (ORCID: https://orcid.org/0009-0005-6781-4441)
- Vijay Kothari
- Dilip Mehta
Institutions
- Nirma University (IN)
- USV (India) (IN)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-22
- DOI
- https://doi.org/10.64898/2025.12.18.695325
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health