<i>Withania somnifera</i> root extract reduces susceptibility of the model worm <i>Caenorhabditis elegans</i> to different types of stressors

Adaptogenic potential of <i>W. somnifera</i> roots was demonstrated in worm model. WSRE can be said to possess a wide anti-stress spectrum as it protected the worms against different stressors inducing toxicity through different mechanisms including interference with acetylcholine and dopamine neurons and function. Our results support the candidature of <i>W. somnifera</i> roots as a potent nutraceutical.

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Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2025-12-22
DOI
https://doi.org/10.64898/2025.12.18.695325
Primary Topic
Genetics, Aging, and Longevity in Model Organisms
Type
article
Field-Weighted Citation Impact
0.00

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article

Withania somnifera root extract reduces susceptibility of the model worm Caenorhabditis elegans to different types of stressors

Nidhi Thakkar, Vijay Kothari, Dilip Mehta
bioRxiv (Cold Spring Harbor Laboratory)
Genetics, Aging, and Longevity in Model Organisms
article

Withania somnifera root extract reduces susceptibility of the model worm Caenorhabditis elegans to different types of stressors

Nidhi Thakkar, Vijay Kothari, Dilip Mehta
article en

Abstract

Adaptogenic potential of <i>W. somnifera</i> roots was demonstrated in worm model. WSRE can be said to possess a wide anti-stress spectrum as it protected the worms against different stressors inducing toxicity through different mechanisms including interference with acetylcholine and dopamine neurons and function. Our results support the candidature of <i>W. somnifera</i> roots as a potent nutraceutical.

bioRxiv (Cold Spring Harbor Laboratory)
Nirma University (IN), USV (India) (IN)
National Institutes of Health
Openalex Percentile: Top 39%
Genetics, Aging, and Longevity in Model Organisms
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