3-Mercaptopyruvate Sulfurtransferase (MPST) Regulates Mitochondrial Metabolism and Epithelial Differentiation in Neonatal Patient-derived Airway Cells
This study identifies MPST as a previously unrecognized regulator of neonatal airway epithelial development. In our neonatal patient-derived three-dimensional organotypic model, hyperoxia reduces MPST, and MPST loss alters mitochondrial metabolism and epithelial differentiation programs. These findings indicate that MPST deficiency contributes to mitochondrial dysfunction under hyperoxic conditions and highlight MPST-linked pathways as potential therapeutic targets to mitigate early-life airway injury and remodeling relevant to infants with bronchopulmonary dysplasia.
Authors
- Abhrajit Ganguly (ORCID: https://orcid.org/0000-0003-1937-243X)
- Lynette K. Rogers (ORCID: https://orcid.org/0000-0003-3413-5379)
- Paul T. Pierce
- Matthew S. Walters (ORCID: https://orcid.org/0000-0003-0010-8444)
- Trent E. Tipple (ORCID: https://orcid.org/0000-0002-5156-4282)
- Aristides Rivera Negron
- Arlan Richardson
- Y S Prakash
- Cynthia M. Carter
Institutions
- University of Central Oklahoma (US)
- WinnMed (US)
- University of Oklahoma Medical Center (US)
- University of Oklahoma Health Sciences Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-22
- DOI
- https://doi.org/10.64898/2025.12.18.695204
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Presbyterian Health Foundation
- National Institutes of Health