Novel pan-cancer T cell exhaustion signature forecasts immunotherapy response and unveils BCAP31 in macrophages as a therapeutic target in neuroblastoma
Our study provides pan-cancer STMN2.SIG as an outperforming approach for patient selection of immunotherapy, and advances our understanding of TAM biology and suggests potential therapeutic strategies for downregulation of BCAP31 in TAMs.
Authors
- J. Zhu (ORCID: https://orcid.org/0000-0002-6186-1408)
- Chenghao Zhanghuang (ORCID: https://orcid.org/0000-0001-6421-767X)
- Fengming Ji
- Hao‐Yu Tang (ORCID: https://orcid.org/0000-0002-6488-3565)
- Shan Li
- Bing Yan
- Ling Liu
- Jinrong Li
- Zhigang Yao
- Xiang Huang
Institutions
- Kunming Medical University (CN)
- Kunming Children's Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1709225
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00