Novel Schiff base-Pt( <scp>ii</scp> ) complexes: inhibition of Aβ aggregation <i>via</i> histidine interaction
Three novel Schiff base–Pt( ii ) complexes were synthesized and characterized. Complexes I and III showed significant anti-amyloid activity by inhibiting Aβ 1–42 peptide aggregation in vitro , with potential to cross the blood–brain barrier.
Authors
- Umut Doğan (ORCID: https://orcid.org/0000-0001-6283-528X)
- S. İrişli (ORCID: https://orcid.org/0000-0002-3727-2216)
- Salih Günnaz (ORCID: https://orcid.org/0000-0002-7422-6593)
- Onur Şahi̇n (ORCID: https://orcid.org/0000-0001-7816-1443)
- Fatma Yurt
Institutions
- Ege University (TR)
- Sinop University (TR)
Publication Details
- Journal
- New Journal of Chemistry
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1039/d5nj04180e
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00