Therapeutic effectiveness of conditioned medium derived from adipose tissue mesenchymal stem cells and dehydroepiandrosterone in a rat model of spinal cord injury
The administration of DHEA and AD-MSC-conditioned medium, particularly in combination, appears to enhance motor function, elevate antioxidant enzyme activity, reduce lipid peroxidation, improve spinal cord structural parameters (volume and cell counts), and ameliorate pathological markers in an animal model of compressive SCI.
Authors
- Mehdi Raei
- Gholam Reza Kaka (ORCID: https://orcid.org/0000-0003-1161-2654)
- Farrokh Modarresi
- Fatemeh Rezaei-Tazangi
Institutions
- Baqiyatallah University of Medical Sciences (IR)
- Fasa University of Medical Sciences (IR)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1016/j.ibneur.2025.12.010
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Baqiyatallah University of Medical Sciences
- Fasa University of Medical Sciences