Hippocampal Beta-Amyloid Accumulation In Aluminium Chloride and D-Galactose-Induced Rats: Establishing a Nontransgenic Alzheimer’s Model
Combined AlCl<sub>3</sub> and D-gal administration successfully induced significant beta-amyloid accumulation in the hippocampal CA2 region, validating this nontransgenic model for investigating AD pathogenesis. This model provides a valuable platform for studying sporadic AD mechanisms and evaluating potential therapeutic interventions.
Authors
- Thirupathirao Vishnumukkala
- Saravanan Jagadeesan
- Prarthana Kalerammana Gopalakrishna
- Nurul H. Mohd Nor
- Samaila M. Chiroma
- Sreenivasulu Sura
- Mohamad A. Mohd Moklas
Institutions
- Universiti Putra Malaysia (MY)
- Newcastle University Medicine Malaysia (MY)
- Mahsa University (MY)
- Taylor's University (MY)
- IMU University (MY)
Publication Details
- Journal
- Journal of Pharmacy And Bioallied Sciences
- Published
- 2025-10-01
- DOI
- https://doi.org/10.4103/jpbs.jpbs_1539_25
- Primary Topic
- Aluminum toxicity and tolerance in plants and animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00