Microbiome dysbiosis and chemotherapy resistance in acute myeloid leukemia (AML)

AML often relapses due to chemotherapy resistance, increasingly linked to gut microbiome dysbiosis. Microbial drug modification, immune modulation, and metabolite-driven survival/epigenetic changes (e.g., SCFAs, kynurenine) promote resistance. Clinical data associate reduced diversity, loss of Faecalibacterium, and Enterococcus overgrowth with poorer outcomes. Microbiome interventions (FMT, probiotics, diet) show promise; priorities are standardizing methods and defining microbe-metabolite mechanisms to guide trials.

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Publication Details

Journal
npj Biofilms and Microbiomes
Published
2025-12-22
DOI
https://doi.org/10.1038/s41522-025-00891-8
Primary Topic
Gut microbiota and health
Type
article
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Microbiome dysbiosis and chemotherapy resistance in acute myeloid leukemia (AML)

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Microbiome dysbiosis and chemotherapy resistance in acute myeloid leukemia (AML)

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article en

Abstract

AML often relapses due to chemotherapy resistance, increasingly linked to gut microbiome dysbiosis. Microbial drug modification, immune modulation, and metabolite-driven survival/epigenetic changes (e.g., SCFAs, kynurenine) promote resistance. Clinical data associate reduced diversity, loss of Faecalibacterium, and Enterococcus overgrowth with poorer outcomes. Microbiome interventions (FMT, probiotics, diet) show promise; priorities are standardizing methods and defining microbe-metabolite mechanisms to guide trials.

npj Biofilms and MicrobiomesVol. 12(1)
Iran University of Medical Sciences (IR), Shiraz University of Medical Sciences (IR), Shahid Sadoughi University of Medical Sciences and Health Services (IR), High Institute for Education and Research in Transfusion Medicine (IR), Central Hospital of Zibo (CN), Shahid Beheshti University of Medical Sciences (IR)
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Openalex Percentile: Top 37%
Gut microbiota and health
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