PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation
Overall, the results indicate that PCSK9 inhibition via evolocumab exhibits substantial promise in the prevention of MP-induced endothelial dysfunction, suggesting the PCSK9-SIRT6 axis as a new promising pathway to target in preventive strategies for cardiovascular risk caused by plastic pollution.
Authors
- Vitale Del Vecchio (ORCID: https://orcid.org/0000-0002-7323-4444)
- Isabella Donisi
- Raffaele Marfella
- Valeria Pellegrini
- Giuseppe Paolisso
- Francesco Prattichizzo
- Maria Luisa Balestrieri
- Michelangela Barbieri
- Nunzia D’Onofrio
- Antonio Ceriello
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- MultiMedica (IT)
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s11658-025-00838-z
- Primary Topic
- Microplastics and Plastic Pollution
- Type
- article
- Field-Weighted Citation Impact
- 0.00