Effectiveness and Impact of Maternal RSV Immunization and Nirsevimab on Medically Attended RSV in US Children
According to the results of this population-based surveillance study, during 2024-2025, both maternal RSV vaccine and nirsevimab were estimated to be effective at protecting infants from RSV-associated hospitalizations in their first RSV season, and RSV-associated hospitalization rates in newborns and infants aged 0 to 11 months were reduced by up to half compared to seasons before these products were introduced.
Authors
- Bonnie Strelitz
- Gina Weddle
- Tess Stopczynski
- Jennifer E. Schuster
- Daniel C. Payne (ORCID: https://orcid.org/0000-0002-5871-911X)
- Nida Mohammad
- Kristina Betters (ORCID: https://orcid.org/0000-0002-3879-6660)
- Jim Chappell
- Danielle M. Zerr (ORCID: https://orcid.org/0000-0003-2944-7554)
- Miranda Howard
- N Halasa
- Chelsea C. Rohlfs
- Geoffrey A. Weinberg (ORCID: https://orcid.org/0000-0002-3900-379X)
- Laura L. Loftis (ORCID: https://orcid.org/0000-0002-2446-3320)
- Claudia Guevara Pulido
- Lynne M. Shelley (ORCID: https://orcid.org/0000-0002-5500-1751)
- Ayzsa Tannis (ORCID: https://orcid.org/0000-0002-0396-0264)
- Anjana Sasidharan (ORCID: https://orcid.org/0009-0008-7559-1796)
- Mary E. Moffat
- Mary Allen Staat (ORCID: https://orcid.org/0000-0003-1788-8037)
- John V. Williams (ORCID: https://orcid.org/0000-0001-8377-5175)
- Christina Albertin
- Megan Freeman
- Alexander L. Greninger (ORCID: https://orcid.org/0000-0002-7443-0527)
- Leah Goldstein
- Laura S Stewart (ORCID: https://orcid.org/0000-0001-6867-2223)
- Klancie Dauer
- Janet A. Englund (ORCID: https://orcid.org/0000-0003-1134-4178)
- Marian G. Michaels (ORCID: https://orcid.org/0000-0002-2556-0544)
- Rachel E. Rutkowski
- Teresa Lin
- Indira Elangovan
- Leila C. Sahni (ORCID: https://orcid.org/0000-0002-0833-5695)
- Tricia S. Williams (ORCID: https://orcid.org/0000-0003-0961-1345)
- Wende Fregoe
- Dinah Dosdos
- Fatimah S Dawood
- Samar Musa
- Kirsten Lacombe (ORCID: https://orcid.org/0000-0003-0299-9447)
- Christina. Legido Quigley
- Monika Johnson
- Dithi Banerjee (ORCID: https://orcid.org/0009-0008-5005-736X)
- J Boom
- Jaimie C. Grams
- Heidi Arth
- Eva Caudill
- Amy Ostrow
- Krirsten Weltmer
- Abigail Salthouse
- Amelia Zazzera
- Laura Ospina Restrepo
- Ariana P. Toepfer
- Marylin Rice
- Alyssa Masten
- Robert Hickey
- Sara Joan J Cregeen
- Josh Sanders
- Heidi L. Moline
- Jenna Snyder
- Flor Munoz
- Claire Smith
- Caymden Hughes
- Rangaraj Selvarangan
- Emma Claire Gauthier
- Pedro (Tony) Piedra
- Vasanthi Avadhanula
- Rafael De La O
- New Vaccine Surveillance Network Collaborators
- Monet Tosch-Berneburg
- Andrew Spieker
- Elizabeth Schlaudecker
- Jamie Costales
- Rebecca Wilber
- Peter G. Szilagyi
- Haya Hayek
- Eileen J. Klein
- Olla Hamdan
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Centers for Disease Control and Prevention (US)
- Seattle Children's Hospital (US)
- Children's Mercy Hospital (US)
- University of Wisconsin–Madison (US)
- University of Pittsburgh (US)
- Baylor College of Medicine (US)
- National Center for Immunization and Respiratory Diseases (US)
- University of Washington (US)
- United States Public Health Service (US)
- Los Angeles Medical Center (US)
- Texas Children's Hospital (US)
- University of Rochester (US)
- Vanderbilt University Medical Center (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- JAMA Pediatrics
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1001/jamapediatrics.2025.5778
- Citations
- 5
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 6.77