Identification of coilin in bone marrow as a potential neuroblastoma tumor progression marker transcriptionally regulated by MYCN
A novel and accessible coilin-targeted liquid biopsy method was developed, capable of detecting minimal residual disease (MRD) in early-stage NB and predicting disease progression and recurrence. Coilin was transcriptionally regulated by MYCN, offering potential avenues for the development of novel drugs or intervention strategies.
Authors
- Sidou He
- Zhixia Yue
- S P Liu
- Wen Zhao (ORCID: https://orcid.org/0000-0003-4566-5914)
- Chunying Cui (ORCID: https://orcid.org/0000-0001-7000-9412)
- Chao Duan (ORCID: https://orcid.org/0000-0003-4423-2156)
- Lan Li (ORCID: https://orcid.org/0000-0002-4657-0864)
- Chao Gao
- Tianlin Xue
- Yan Su
Institutions
- Capital Medical University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- Cancer Biology & Therapy
- Published
- 2025-12-21
- DOI
- https://doi.org/10.1080/15384047.2025.2600709
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00