Metabolic response to extended continuous positive airway pressure in premature infants
Discontinuing CPAP in premature infants recovering from respiratory distress altered levels of 14% of detected blood metabolites within 1 week and reduced gain in lung function and body weight at 2 weeks. Biochemical sub pathway enrichment occurred for acylcarnitines with higher circulating levels of 22 fatty acid metabolites in infants coming off CPAP. Extending CPAP beyond the current guidelines for discontinuation may reduce the work of breathing, improve mitochondrial utilization of fatty acids, and provide more energy for lung development and body growth.
Authors
- Alexios Martin
- Cheryl Chapin
- Mitzi Go (ORCID: https://orcid.org/0000-0001-7098-3223)
- R. Tepper
- Kelvin D. MacDonald (ORCID: https://orcid.org/0000-0002-6716-8559)
- Kristin Milner
- Philip L. Ballard (ORCID: https://orcid.org/0000-0002-5948-4092)
- Dara G. Torgerson
- T. Malave-Mendez
- Julia Harris
- Cindy T. McEvoy
Institutions
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1038/s41390-025-04670-1
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of California, San Francisco
- National Heart, Lung, and Blood Institute