Nickel-catalyzed reductive coupling of secondary alkyl bromides with alkynes to construct allylic difluoromethyl alkenes
We report a highly efficient and broadly applicable nickel-hydride-catalyzed reductive cross-coupling of unactivated CF<sub>2</sub>H-substituted electrophiles with diverse alkynes. The reaction proceeds with excellent catalytic efficiency and functional group tolerance, providing a powerful platform for the late-stage fluoroalkylation of complex drug molecules.
Authors
- Xiaojun Zeng (ORCID: https://orcid.org/0000-0002-9425-4882)
- Jiaming Chen (ORCID: https://orcid.org/0000-0003-4376-0061)
- Yanli Yuan
- Jinxu Dong
- Xiaohong Wen
- Yihang Xu
Institutions
- Nanchang University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1039/d5cc06347g
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00