The mechanism of prostaglandin E2 upregulation of programmed death ligand 1 expression promoting immune escape in non-small cell lung cancer

This study confirmed that PGE2 promotes immune evasion of NSCLC by upregulating PD-L1, and the mechanism involves the activation of the PI3K/AKT/mTOR pathway. This research provides a novel theoretical basis for immunotherapy of NSCLC and emphasizes the clinical value of PTGES/PGE2 as a potential target.

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Publication Details

Journal
CytoJournal
Published
2025-12-22
DOI
https://doi.org/10.25259/cytojournal_129_2025
Primary Topic
Inflammatory mediators and NSAID effects
Type
article
Field-Weighted Citation Impact
0.00
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article

The mechanism of prostaglandin E2 upregulation of programmed death ligand 1 expression promoting immune escape in non-small cell lung cancer

Sen Liu, Lei Liu, Tian Wang
CytoJournal
Inflammatory mediators and NSAID effects
article

The mechanism of prostaglandin E2 upregulation of programmed death ligand 1 expression promoting immune escape in non-small cell lung cancer

Sen Liu, Lei Liu, Tian Wang
article en

Abstract

This study confirmed that PGE2 promotes immune evasion of NSCLC by upregulating PD-L1, and the mechanism involves the activation of the PI3K/AKT/mTOR pathway. This research provides a novel theoretical basis for immunotherapy of NSCLC and emphasizes the clinical value of PTGES/PGE2 as a potential target.

CytoJournalVol. 22
Beijing VDJBio (China) (CN), Jinan Central Hospital (CN), Yantaishan Hospital (CN), Shandong First Medical University (CN)
Good health and well-being
Openalex Percentile: Top 31%
Inflammatory mediators and NSAID effects
DOIOpen Access PDFOpenAlex
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