Association between glucagon‐like peptide‐1 receptor agonists and risk of dementia in older adults with type 2 diabetes: A target trial emulation
In this large real-world cohort, GLP-1 RAs were associated with lower dementia risk than DPP4is but higher risk than SGLT2is. Prospective, biomarker-informed studies are needed to clarify mechanisms and inform treatment choices in older adults with T2D.
Authors
- HUILIN TANG
- Yiwen Lu (ORCID: https://orcid.org/0009-0000-9591-2261)
- Jiajie Chen (ORCID: https://orcid.org/0009-0008-7402-6883)
- Bingyu Zhang
- David A Asch
- Dazheng Zhang (ORCID: https://orcid.org/0000-0001-7335-4983)
- Lu Li
- Ting Zhou
- Yong Chen
Institutions
- University of the Sciences (US)
- Pfizer (United States) (US)
- University of the Arts (US)
- Penn Center for AIDS Research (US)
- Science History Institute (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1111/dom.70384
- Citations
- 1
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.29