Dynamic Landscape of H3K4me3 and H3K27me3 Modification During Postnatal Leydig Cell Fate Determination
Our work identifies an H3K4me3/H3K27me3-transcription factors (TFs)-target gene axis as a central regulatory mechanism governing postnatal Leydig cell differentiation. This discovery clarifies how this axis endows Leydig cells with steroidogenic potential while suppressing stemness properties.
Authors
- Lvjing Luo (ORCID: https://orcid.org/0009-0003-7985-5801)
- Z. Lin
- Xiuli Lian (ORCID: https://orcid.org/0000-0001-9171-5789)
- M L Zheng
- Dini Zhang
- Shanshan Luo
- Xuanyi Wang
- Shie Wang
- Jiandong Sun
Institutions
- Fujian Medical University (CN)
Publication Details
- Journal
- Andrology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1111/andr.70165
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fujian Medical University