Non-invasive biomarkers in pediatric MASLD: utility of gamma-glutamyltransferase for steatohepatitis and the FIB-4 index for fibrosis

The findings of this study suggest that the FIB-4 index may have some utility in identifying advanced fibrosis in pediatric MASLD, although its performance might be limited compared to adult cohorts. Furthermore, GGT shows promise as a simple and non-invasive biomarker for distinguishing MASH from simple steatosis in children. Integrating GGT into future screening protocols could contribute to improved risk stratification, potentially aiding in the identification of high-risk patients who may benefit from earlier, more intensive clinical interventions or prioritized consideration for liver biopsy.