<scp>BK</scp> Polyomavirus in Pediatric Kidney Transplant Recipients: Incidence, Risk Factors, <scp>dnDSA</scp> Development, and the Role of <scp>IVIG</scp>

The findings of our study suggest a potential benefit of stringent BKV screening and considering timely and intensive treatments before graft dysfunction becomes apparent. Our research also indicates that IVIG might be effective in managing both confirmed and presumptive BKVAN cases, as evidenced by the similar graft outcome observed after a 3-year follow-up period post BKV DNAmia. Notably, despite more frequent adjustments to immunosuppressants and a higher rate of human leukocyte antigen (HLA) mismatch in the BKV DNAemia group, the incidence of dnDSA formation appeared to be comparable between the two groups. These observations warrant controlled trials to confirm their broad applicability.

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Publication Details

Journal
Pediatric Transplantation
Published
2025-12-22
DOI
https://doi.org/10.1111/petr.70255
Primary Topic
Polyomavirus and related diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

BK Polyomavirus in Pediatric Kidney Transplant Recipients: Incidence, Risk Factors, dnDSA Development, and the Role of IVIG

A. azzam, Mohammed Almaghrabi, Alanoud Alshami, Ammar Hamed et al.
Pediatric Transplantation
Polyomavirus and related diseases
article

BK Polyomavirus in Pediatric Kidney Transplant Recipients: Incidence, Risk Factors, dnDSA Development, and the Role of IVIG

A. azzam, Mohammed Almaghrabi, Alanoud Alshami, Ammar Hamed, Abeer Alessa, Hebatalla Bahbah, Nasreen Mohammed
article en

Abstract

The findings of our study suggest a potential benefit of stringent BKV screening and considering timely and intensive treatments before graft dysfunction becomes apparent. Our research also indicates that IVIG might be effective in managing both confirmed and presumptive BKVAN cases, as evidenced by the similar graft outcome observed after a 3-year follow-up period post BKV DNAmia. Notably, despite more frequent adjustments to immunosuppressants and a higher rate of human leukocyte antigen (HLA) mismatch in the BKV DNAemia group, the incidence of dnDSA formation appeared to be comparable between the two groups. These observations warrant controlled trials to confirm their broad applicability.

Pediatric TransplantationVol. 30(1)
King Fahad Specialist Hospital (SA)
Good health and well-being
Openalex Percentile: Top 32%
Polyomavirus and related diseases
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