Retinal pigment epithelium-derived extracellular vesicles mediate outer blood retinal barrier disruption in response to AMD-related stress
Our findings reveal a novel EV-driven mechanism contributing to retinal degeneration progression, highlighting inflammation-derived apical EVs as key players in diseases involving oBRB dysfunction. Targeting EV-mediated signaling and MMPs activity may offer therapeutic strategies for preserving retinal structure and function in inflammatory retinal diseases such as age-related macular degeneration.
Authors
- Raquel Boia (ORCID: https://orcid.org/0000-0002-0479-3066)
- Teresa Ribeiro‐Rodrigues (ORCID: https://orcid.org/0000-0002-5169-6090)
- Rosa Anita Fernandes (ORCID: https://orcid.org/0000-0003-3291-7502)
- António Francisco Ambrósio (ORCID: https://orcid.org/0000-0002-0477-1641)
- Beatriz Duarte Martins (ORCID: https://orcid.org/0000-0002-2132-3461)
- Diana Correia (ORCID: https://orcid.org/0000-0002-9164-9774)
- Henrique M. Girão
- José Ramalho
Institutions
- Association for Innovation and Biomedical Research on Light and Image (PT)
- Instituto Português de Oncologia de Coimbra Francisco Gentil (PT)
- University of Coimbra (PT)
- Fundação para a Ciência e Tecnologia (PT)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s12964-025-02587-0
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71