Compressed-sensing enabled forward-viewing M-mode OCT for large field of view imaging

We present a method for generating large field of view three-dimensional images with a forward-viewing M-mode optical coherence tomography (OCT) probe that combines electromagnetic tracking with a compressed-sensing iterative soft-thresholding algorithm (CS-ISTA). Phantom and ex-vivo porcine studies demonstrate accurate 3D reconstruction of undersampled volumes and high-contrast tissue sample attenuation maps that delineate pulmonary vein from atrial tissue through blood, with an 88% compression rate with respect to Nyquist. This approach delivers the speed and image quality needed to guide radio-frequency ablation and other catheter-based interventions.