Effects of resveratrol on CYP450-derived arachidonic acid metabolites and mRNA gene expression in human endothelial HUVEC cells
These findings suggest that resveratrol significantly reduces the levels of EETs and DHETEs possibly through direct interaction with CYP2J2. Furthermore, HUVECs may not be a suitable <i>in vitro</i> model for studying ARA metabolism to 20-HETE.
Authors
- Arwa R. Althaher (ORCID: https://orcid.org/0000-0002-8778-0104)
- Ala’a S. Shraim (ORCID: https://orcid.org/0000-0001-7021-8847)
- Fatima Khirfan
- Yazun Jarrar (ORCID: https://orcid.org/0000-0002-5943-7229)
- Su-Jun Lee
- Mansour Al-Sayed Ahmad
- W. Nasser
Institutions
- Inje University (KR)
- Al-Ahliyya Amman University (JO)
- Al-Zaytoonah University of Jordan (JO)
- Al-Balqa Applied University (JO)
Publication Details
- Journal
- Journal of Complementary and Integrative Medicine
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1515/jcim-2025-0194
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00