<scp> <i>GREB1</i> </scp> ‐rearranged uterine tumour shares a common <scp>DNA</scp> methylation signature with <scp> <i>ESR1</i> </scp> ‐rearranged <scp>UTROSCT</scp>

Overall, our findings confirm that GREB1-rearranged uterine tumours are part of the UTROSCT spectrum, though they frequently exhibit a more diffuse growth pattern and a higher degree of genomic instability.

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Publication Details

Journal
Histopathology
Published
2025-12-22
DOI
https://doi.org/10.1111/his.70075
Primary Topic
Chromatin Remodeling and Cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

GREB1 ‐rearranged uterine tumour shares a common DNA methylation signature with ESR1 ‐rearranged UTROSCT

David L. Kolin, Jennifer A. Bennett, Mark Sementsov, Andreas von Deimling et al.
Histopathology
Chromatin Remodeling and Cancer
article

GREB1 ‐rearranged uterine tumour shares a common DNA methylation signature with ESR1 ‐rearranged UTROSCT

David L. Kolin, Jennifer A. Bennett, Mark Sementsov, Andreas von Deimling, Hsuan‐Ying Huang, Brendan C. Dickson, Yow‐Shan Lee, Jen‐Chieh Lee, Christian Koelsche, Martin Köbel, Friedrich Kommoss, Felix K F Kommoss, Cheng‐Han Lee
article en

Abstract

Overall, our findings confirm that GREB1-rearranged uterine tumours are part of the UTROSCT spectrum, though they frequently exhibit a more diffuse growth pattern and a higher degree of genomic instability.

HistopathologyVol. 88(5)
Brigham and Women's Hospital (US), University of Alberta (CA), University of Calgary (CA), Chang Gung University (TW), Heidelberg University (DE), University Hospital Heidelberg (DE), University of Chicago Medical Center (US), Kaohsiung Chang Gung Memorial Hospital (TW), Medizin Campus Bodensee (DE), Cathay General Hospital (TW), Sinai Health System (CA), National Taiwan University Hospital (TW), DKFZ-ZMBH Alliance (DE), Ludwig-Maximilians-Universität München (DE)
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Chromatin Remodeling and Cancer
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