Clinicopathologic Correlation in a Case of Scurvy

Scurvy is an uncommon diagnosis in developed countries, yet it remains an important clinical consideration in patients with restrictive diets. In this study, we report a case of a male patient with a history of sclerosing mesenteritis and chronic dietary restriction who presented with bilateral leg purpura, perifollicular hemorrhage, and gingival bleeding. His cutaneous findings initially raised concern for vasculitis or coagulopathy. However, histopathology revealed classic features of scurvy and an undetectable vitamin C level confirmed the diagnosis. Oral vitamin C supplementation led to rapid clinical improvement. This case emphasizes the importance of a thorough dietary history and skin examination in patients presenting with mucocutaneous bleeding.

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Publication Details

Journal
American Journal of Dermatopathology
Published
2025-12-22
DOI
https://doi.org/10.1097/dad.0000000000003200
Primary Topic
Vitamin C and Antioxidants Research
Type
article
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article

Clinicopathologic Correlation in a Case of Scurvy

Jamie Zussman, Nathanael C. Jensen, Dekker C. Deacon, Katherine Gillis
American Journal of Dermatopathology
Vitamin C and Antioxidants Research
article

Clinicopathologic Correlation in a Case of Scurvy

Jamie Zussman, Nathanael C. Jensen, Dekker C. Deacon, Katherine Gillis
article en

Abstract

Scurvy is an uncommon diagnosis in developed countries, yet it remains an important clinical consideration in patients with restrictive diets. In this study, we report a case of a male patient with a history of sclerosing mesenteritis and chronic dietary restriction who presented with bilateral leg purpura, perifollicular hemorrhage, and gingival bleeding. His cutaneous findings initially raised concern for vasculitis or coagulopathy. However, histopathology revealed classic features of scurvy and an undetectable vitamin C level confirmed the diagnosis. Oral vitamin C supplementation led to rapid clinical improvement. This case emphasizes the importance of a thorough dietary history and skin examination in patients presenting with mucocutaneous bleeding.

American Journal of DermatopathologyVol. 48(3)
University of Utah (US), Huntsman Cancer Institute (US)
Partnerships for the goals
Openalex Percentile: Top 36%
Vitamin C and Antioxidants Research
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