Association of the p.Phe155del mutation in SERPINC1 with changed antithrombin function and increased risk of venous thromboembolism: clinical and functional observations
This reduced binding may underlie hereditary AT deficiency and increased venous thrombosis risk. The findings from this research deepen understanding of the connection between hereditary hypercoagulable states and VTE -with CVST as one possible clinical manifestation-offering new insights to inform clinical diagnosis and treatment.
Authors
- J. Zhang
- Yining Lan (ORCID: https://orcid.org/0000-0002-2937-1871)
- Jing Lü (ORCID: https://orcid.org/0000-0001-6017-326X)
- Zhilin Yu
- Yanyan Tang
- Zuoyu Qin
- Jialan Liang
Institutions
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Thrombosis Journal
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s12959-025-00802-z
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province
- Guangxi Medical University