Folate receptor alpha in platinum-resistant ovarian cancer: prevalence in a multicenter Polish cohort and review of the evidence

Approximately half of the ovarian cancer patients in this multicenter Polish cohort demonstrated FOLR1 positivity. Although this prevalence is lower than that reported in high-grade serous carcinoma cohorts, it likely reflects histological heterogeneity and methodological differences between studies. These findings provide the first population-based evidence from Poland and support the implementation of FOLR1 testing to guide access to mirvetuximab soravtansine. Further research integrating clinical and molecular data is warranted to validate these results and assess implications for cost-effectiveness and patient outcomes.

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Publication Details

Journal
Clinical & Translational Oncology
Published
2025-12-22
DOI
https://doi.org/10.1007/s12094-025-04179-3
Primary Topic
Folate and B Vitamins Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Folate receptor alpha in platinum-resistant ovarian cancer: prevalence in a multicenter Polish cohort and review of the evidence

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Clinical & Translational Oncology
Folate and B Vitamins Research
article

Folate receptor alpha in platinum-resistant ovarian cancer: prevalence in a multicenter Polish cohort and review of the evidence

Łukasz Szylberg, Justyna Durślewicz, Jędrzej Borowczak, Monika Durzyńska, Jakub Cheliński, Maria Filipek, Marek Zdrenka
article en

Abstract

Approximately half of the ovarian cancer patients in this multicenter Polish cohort demonstrated FOLR1 positivity. Although this prevalence is lower than that reported in high-grade serous carcinoma cohorts, it likely reflects histological heterogeneity and methodological differences between studies. These findings provide the first population-based evidence from Poland and support the implementation of FOLR1 testing to guide access to mirvetuximab soravtansine. Further research integrating clinical and molecular data is warranted to validate these results and assess implications for cost-effectiveness and patient outcomes.

Clinical & Translational Oncology
Bydgoszcz University of Science and Technology (PL), Nicolaus Copernicus University (PL), University of Bydgoszcz (PL), The Maria Sklodowska-Curie National Research Institute of Oncology (PL), AGH University of Krakow (PL), University of Rzeszów (PL)
Good health and well-being
Openalex Percentile: Top 28%
Folate and B Vitamins Research
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