Engineering Chimeric Hypoallergens for Safer and More Effective House Dust Mite Allergy Vaccines
Summary Box Chimeric hypoallergens of Der p 1 and Blo t 1 (QBD2/QBD4) reduce IgE reactivity and airway inflammation in mice. QBD4 promotes Th1/regulatory responses, suppressing mucus and eosinophilia more effectively than QBD2.
Authors
- Elisânia Fontes Silveira (ORCID: https://orcid.org/0000-0003-4936-5986)
- Sara Huber (ORCID: https://orcid.org/0000-0003-3589-4924)
- Deise Souza Vilas‐Bôas
- Peter Lackner (ORCID: https://orcid.org/0000-0003-4681-6307)
- Eduardo Sérgio da Silva (ORCID: https://orcid.org/0000-0001-7409-9216)
- Leonardo Freire Santiago
- Peter Briza (ORCID: https://orcid.org/0000-0002-4941-6782)
- Tafarel Souza
- Alex Fernandes
- Luis G. C Pacheco (ORCID: https://orcid.org/0000-0003-2500-0800)
- Raphael C. Silva
- Luis F. S. Garcés
- Fatima Ferreira
- Neuza M. Alcântara‐Neves
- Sabrina Wildner
- Lorena M. de Souza
- Vitor S. Alves
- Carina S. Pinheiro
Institutions
- Universidade Federal da Bahia (BR)
- University of Salzburg (AT)
- Universidad Técnica de Ambato (EC)
- Universidade Federal de Uberlândia (BR)
Publication Details
- Journal
- Clinical & Experimental Allergy
- Published
- 2025-12-21
- DOI
- https://doi.org/10.1111/cea.70197
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universität Salzburg