Life’s essential 8 scores and acute myocardial infarction: Associations with risk, onset delay, and scenario-based preventable fraction estimates

<b>:</b> Higher CVH levels were associated with reduced AMI risk and delayed onset, with inflammatory and metabolic biomarkers partially mediating this relationship. In the low-CVH group, a hypothetical shift to higher CVH levels was associated with a scenario-based population attributable fraction of approximately 60 %, highlighting the potential population impact of improving cardiovascular health.