Incretin-Based Therapies and Post–Bariatric Surgery Alcohol Use Disorder

In this cohort study of patients who underwent bariatric surgery, IBT was associated with a 55% lower risk of new-onset AUD and a 41% lower risk of initiation of MAUDs compared with non-IBT AOMs. These findings suggest potential neurobehavioral benefits associated with IBTs that may inform AOM selection in this high-risk population. Prospective studies are warranted to confirm these associations and examine long-term liver-related outcomes.

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Publication Details

Journal
JAMA Network Open
Published
2025-12-22
DOI
https://doi.org/10.1001/jamanetworkopen.2025.49086
Primary Topic
Bariatric Surgery and Outcomes
Type
article
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article

Incretin-Based Therapies and Post–Bariatric Surgery Alcohol Use Disorder

Vinay Jahagirdar, Butros Fakhoury, JuanPablo Arab, Luis Antonio Diaz et al.
JAMA Network Open
Bariatric Surgery and Outcomes
article

Incretin-Based Therapies and Post–Bariatric Surgery Alcohol Use Disorder

Vinay Jahagirdar, Butros Fakhoury, JuanPablo Arab, Luis Antonio Diaz, Kaanthi Rama, Leandro Sierra
article en

Abstract

In this cohort study of patients who underwent bariatric surgery, IBT was associated with a 55% lower risk of new-onset AUD and a 41% lower risk of initiation of MAUDs compared with non-IBT AOMs. These findings suggest potential neurobehavioral benefits associated with IBTs that may inform AOM selection in this high-risk population. Prospective studies are warranted to confirm these associations and examine long-term liver-related outcomes.

JAMA Network OpenVol. 8(12)
Cleveland Clinic (US), Pontificia Universidad Católica de Chile (CL), Virginia Commonwealth University (US), University of California San Diego (US)
Good health and well-being
Openalex Percentile: Top 27%
Bariatric Surgery and Outcomes
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