Incretin-Based Therapies and Post–Bariatric Surgery Alcohol Use Disorder
In this cohort study of patients who underwent bariatric surgery, IBT was associated with a 55% lower risk of new-onset AUD and a 41% lower risk of initiation of MAUDs compared with non-IBT AOMs. These findings suggest potential neurobehavioral benefits associated with IBTs that may inform AOM selection in this high-risk population. Prospective studies are warranted to confirm these associations and examine long-term liver-related outcomes.
Authors
- Vinay Jahagirdar (ORCID: https://orcid.org/0000-0001-6685-1033)
- Butros Fakhoury (ORCID: https://orcid.org/0000-0001-6909-6328)
- JuanPablo Arab
- Luis Antonio Diaz
- Kaanthi Rama
- Leandro Sierra
Institutions
- Cleveland Clinic (US)
- Pontificia Universidad Católica de Chile (CL)
- Virginia Commonwealth University (US)
- University of California San Diego (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.49086
- Primary Topic
- Bariatric Surgery and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00