Activating KRAS Mutations Expressed in 3D Endothelial Spheroids Induce Blebbing Morphologies Associated with Amoeboid-like Migration
Endothelial spheroids expressing KRAS<sup>G12V</sup> exhibit characteristic features associated with abnormal vessel development in brain AVMs as well as novel phenotypes not previously observed in 2D monolayers. The ability to extend culture periods in this simple 3D model may allow further phenotypic exploration of important AVM driver mutations.
Authors
- Marcus A. Stoodley
- V. Lee
- Lucinda S. McRobb
Institutions
- Macquarie University (AU)
Publication Details
- Journal
- Cells
- Published
- 2025-12-22
- DOI
- https://doi.org/10.3390/cells15010022
- Primary Topic
- Vascular Malformations Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council
- National Health and Medical Research Council