Serum DLX6-AS1 and miR-141-3p as early diagnostic biomarkers and regulators of delayed fracture healing (DFH)
DLX6-AS1 and miR-141-3p emerge as independent risk indicators and potential diagnostic biomarkers for DFH. By modulating the miR-141-3p/VEGFA axis, DLX6-AS1 influences chondrocyte differentiation and fracture repair, highlighting this pathway as a viable target.
Authors
- Yuan Ruan (ORCID: https://orcid.org/0000-0002-0118-1603)
- Gong Chen
- Jinxiang Zhang
- Mingdong Zhang
Institutions
- Dalian Medical University (CN)
- Anhui Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Baise University (CN)
- Huanggang Central Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s13018-025-06478-5
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00