Single-nucleus RNA sequencing resolves microenvironmental dynamics in brown/beige adipose tissue after bariatric surgery

We delineate post-bariatric microenvironmental reprogramming in thermogenic adipose depots and highlight a candidate pathway in which 11 putative transition regulators cooperate with IGF1 signaling to promote AP6-cell transdifferentiation toward fibroblastoid lineages. These data nominate testable targets for therapeutic modulation of obesity and its complications. Given the limited sample size, findings are descriptive and hypothesis-generating; definitive lineage inference awaits validation by fate mapping or RNA-velocity in larger cohorts.