Systematic review and meta-analysis of humoral immunity proteins and mortality in sepsis
Sepsis non-survivors exhibit lower C3 and C4 levels and higher C4a, consistent with complement activation and/or depletion. Complement proteins may serve as potential biomarkers and therapeutic targets in sepsis.
Authors
- Timothy D. McHugh (ORCID: https://orcid.org/0000-0003-4658-8594)
- Jonas Tverring (ORCID: https://orcid.org/0000-0003-0939-6673)
- Emma Rademaker (ORCID: https://orcid.org/0000-0001-5143-5723)
- Morten Hedetoft (ORCID: https://orcid.org/0000-0002-2606-8041)
- Yuxin Mi
- Derek W. Gilroy (ORCID: https://orcid.org/0000-0003-3476-0844)
- Mikael Bodelsson
- Raymond J. Langley (ORCID: https://orcid.org/0000-0001-8849-9325)
- Stephen F. Kingsmore (ORCID: https://orcid.org/0000-0001-7180-2527)
- Masayuki Akatsuka (ORCID: https://orcid.org/0000-0003-0065-9721)
- M.C. de la Torre Terron
- Julian Charles Knight (ORCID: https://orcid.org/0000-0002-0377-5536)
- Corina C. Heinz (ORCID: https://orcid.org/0000-0003-1702-3914)
- Merry L. Lindsey (ORCID: https://orcid.org/0000-0002-4090-0391)
- Walter Pisciotta (ORCID: https://orcid.org/0000-0002-2470-2416)
- Henning Ebelt (ORCID: https://orcid.org/0000-0003-2465-1812)
- Sven A Kerneis
- Kai Hilpert
- Fabienne Venet (ORCID: https://orcid.org/0000-0003-0462-4235)
- Fiona Dewar
- Gül BATUM
- Jesús F Bermejo-Martin
- Evangelos J. Giamarellos-Bourboulis
- Aline de Nooijer
- Guillaume Monneret
- Pietro Caironi
- Marie Scully
- Tom McDonnell
- Dave Brealey
- Nishkantha Arulkumaran
- Tzu Hsuan Cheng
- Antoine Villa
- Jennifer Meessen
- Mervyn Singer
- Mihai G. Netea
- Ming Zhang
- Ankit Rai
Institutions
- Université Claude Bernard Lyon 1 (FR)
- École Normale Supérieure de Lyon (FR)
- Meharry Medical College (US)
- University of Copenhagen (DK)
- Centre National de la Recherche Scientifique (FR)
- Children’s Institute (US)
- Centre for Human Genetics (GB)
- Sapporo Medical University (JP)
- Radboud University Nijmegen (NL)
- Inserm (FR)
- St George's, University of London (GB)
- SUNY Downstate Health Sciences University (US)
- Lund University (SE)
- Mario Negri Institute for Pharmacological Research (IT)
- National and Kapodistrian University of Athens (GR)
- Bury College (GB)
- Rigshospitalet (DK)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- University of Oxford (GB)
- Rady Children's Hospital-San Diego (US)
- Hospices Civils de Lyon (FR)
- Maresme Health Consortium (ES)
- Nashville VA Medical Center (US)
- Biotest (Germany) (DE)
- Katholisches Krankenhaus St. Johann Nepomuk (DE)
- Instituto de Investigación Biomédica de Salamanca (ES)
- Hospital de Mataró (ES)
- UCL Biomedical Research Centre (GB)
- The London College (GB)
- Centre for Inflammation Research (GB)
- University Hospital in Halle (DE)
- University College London (GB)
- Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IT)
- University of Turin (IT)
- University of South Alabama (US)
Publication Details
- Journal
- Critical Care
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s13054-025-05758-0
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35