Challenges and Strategies in Metabolic Modulation Diets for Longevity: Protocol for the Validation of the FusionMed Antiaging Model

Introduction: To develop and propose the validation of the FusionMed Antiaging (FMA) model, which combines principles from the Mediterranean (MD) and DASH diets with moderate caloric restriction and cultural adaptations to improve adherence and promote longevity and metabolic health. Methods: A 12-week randomized controlled clinical trial is proposed with three groups: Standard Mediterranean Diet, Standard DASH Diet, and the experimental FMA model. Metabolic markers, adherence measures, and general well-being variables will be assessed using descriptive and inferential analyses. The intervention focuses on combining evidence-based principles, such as moderate caloric restriction and a personalized approach, to overcome cultural, economic, and behavioral adherence barriers, facilitating implementation in various settings. A total of 120 adults aged 40 to 70 years, with mild overweight (BMI between 25–30) and no severe metabolic diseases, randomly divided into three intervention groups Results: The FusionMed Antiaging group is expected to show significant improvements in insulin sensitivity, systemic inflammation, body composition, and adherence compared to the control groups. Conclusions: The FMA model presents itself as a promising and adaptable proposal to improve metabolic health and promote healthy aging. Its experimental validation will determine its efficacy and sustainability across diverse contexts and populations.