Very long-chain saturated fatty acids in plasma lipids: association with cardiometabolic risk influenced by lipid interactions
VLCSFA show different metabolic roles in cardiometabolic diseases and highlight the importance of adjusting for confounding by correlated lipids. These findings challenge the traditional view that SFA exert uniform negative effects and suggest class-specific VLCSFA profiles may improve risk prediction of cardiometabolic diseases, guiding more precise prevention strategies.
Authors
- Marcela Prada (ORCID: https://orcid.org/0000-0002-1159-417X)
- Matthias Bernd Schulze (ORCID: https://orcid.org/0000-0002-0830-5277)
- Fabian Eichelmann (ORCID: https://orcid.org/0000-0002-3975-5596)
- Inés Domínguez-López
Institutions
- University of Potsdam (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- German Institute of Human Nutrition (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s12933-025-03037-4
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00