Protective Effects of Estradiol on Disease Progression in a Murine Model of Fuchs Endothelial Corneal Dystrophy
E2 ameliorates FECD progression by suppressing excessive ECM production. Our in vitro data suggest this protective effect is mediated through the inhibition of the TGF-β-Smad signaling pathway. These findings provide critical in vivo evidence for the therapeutic potential of E2, establishing a strong rationale for its clinical investigation as a novel treatment for FECD.
Authors
- Theofilos Tourtas (ORCID: https://orcid.org/0000-0002-3465-9837)
- Naoki Okumura (ORCID: https://orcid.org/0000-0003-2275-5263)
- Ursula Schlötzer‐Schrehardt (ORCID: https://orcid.org/0000-0001-8423-7395)
- Albert S. Jun (ORCID: https://orcid.org/0000-0001-8650-2279)
- Itsuki Oka
- Friedrich Kruse
- Kota Mayumi
- Sohya Fujimoto
- Tomohiro Fukui
- Noriko Koizumi
Institutions
- Doshisha University (JP)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Virginia (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1167/iovs.66.15.64
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science