Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner

Prenatal LPS exposure induces heterogeneous structural and molecular changes in the newborn mice lung, showing LPS dose- and time-dependent modulation of mesenchymal fibroblast differentiation. These findings may contribute to refine the risk stratification of preterm infants exposed to prenatal infection/inflammation. Mesenchymal fibroblast plasticity and MYFs-LIFs phenotypic shifts may inspire preventive and therapeutic strategies for BPD.

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Publication Details

Journal
BMC Medicine
Published
2025-12-22
DOI
https://doi.org/10.1186/s12916-025-04533-w
Primary Topic
Neonatal Respiratory Health Research
Type
article
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article

Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner

Marek Bartkuhn, S. Bellusci, Stefan Hadžić, Harald Ehrhardt et al.
BMC Medicine
Neonatal Respiratory Health Research
article

Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner

Marek Bartkuhn, S. Bellusci, Stefan Hadžić, Harald Ehrhardt, Annika Leidner, Manuela Marega, Tara Procida-Kowalski, Ying Dong, Stefano Rivetti
article en

Abstract

Prenatal LPS exposure induces heterogeneous structural and molecular changes in the newborn mice lung, showing LPS dose- and time-dependent modulation of mesenchymal fibroblast differentiation. These findings may contribute to refine the risk stratification of preterm infants exposed to prenatal infection/inflammation. Mesenchymal fibroblast plasticity and MYFs-LIFs phenotypic shifts may inspire preventive and therapeutic strategies for BPD.

BMC MedicineVol. 24(1)
Justus-Liebig-Universität Gießen (DE), Quzhou City People's Hospital (CN), Helios Universitätsklinikum Wuppertal (DE), Quzhou University (CN), German Center for Lung Research (DE), Universities of Giessen and Marburg Lung Center (DE), Cardio-Pulmonary Institute (DE), University Hospital Ulm (DE), Charité - Universitätsmedizin Berlin (DE)
Good health and well-being
Openalex Percentile: Top 29%
Neonatal Respiratory Health Research
DOIOpen Access PDFOpenAlex
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Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner — Marek Bartkuhn, S. Bellusci, et al. · BMC Medicine (2025) | TGRS Research Map | TGRS