Extracellular matrix-derived mechanical force induces CDK4/6 inhibitor resistance by inhibiting NEK10 dependent cell cycle regulation in breast cancer
This study underscores the critical role of ECM-derived biomechanical forces in regulating CDK4/6 inhibitor resistance in breast cancer and identifies NEK10 as a potential therapeutic target for improving breast cancer treatment.
Authors
- S. Wang
- Ting Du (ORCID: https://orcid.org/0000-0002-9020-3746)
- Huailiang Wu
- Limin H. Chen (ORCID: https://orcid.org/0000-0001-5766-1350)
- S. J. Lin (ORCID: https://orcid.org/0009-0001-9795-1560)
- Wan Wang (ORCID: https://orcid.org/0000-0002-5662-9989)
- Yuming Jin
- Yumeng Huang
- Dongshao Chen
- Cong Li
- Ruoxi Hong
- Jian Wang
- Binghe Xu
Institutions
- Union Hospital (HK)
- Sun Yat-sen University (CN)
- Jilin University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chengdu Medical College (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Fifth Tianjin Central Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- The University of Texas Medical Branch at Galveston (US)
- Tianjin Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1097/js9.0000000000004527
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00