BDH1 acetylation at K116 modulates milk fat production in dairy goats
This study established, for the first time, the comprehensive acetylome of mammary gland tissues in dairy goats, revealing a substantial number of differentially acetylated proteins and modification sites. We demonstrate that acetylation of BDH1 regulated by HDACs promotes lipid droplet biogenesis and triglyceride synthesis in GMECs through transcriptional modulation of key lipogenic genes and suppression of SREBP1. These findings provide mechanistic insights into the post-translational regulation of mammary lipid metabolism and offer molecular targets for future genetic and nutritional strategies aimed at enhancing milk quality and yield in dairy goats.
Authors
- Lu Deng (ORCID: https://orcid.org/0000-0002-3744-4102)
- Xinglong Gong (ORCID: https://orcid.org/0000-0003-4773-977X)
- Juan J. Loor (ORCID: https://orcid.org/0000-0003-1586-4365)
- Cong Li
- Chong Chen (ORCID: https://orcid.org/0000-0002-6787-0495)
- Tiantian Xiong
- Jun Luo
- Chengming Han
- Min Tian
Institutions
- University of Illinois Urbana-Champaign (US)
- North West Agriculture and Forestry University (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1186/s40104-025-01315-5
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China