Cyclin-dependent kinase 10 controls bone formation and is linked to human skeletal health
This research establishes Cyclin-Dependent Kinase 10 (CDK10) as a critical regulator of bone formation. Mouse studies demonstrate that osteoblast-specific Cdk10 deletion causes osteoporosis, mirroring osteopenia in humans with CDK10 mutations. These findings highlight CDK10 as a potential diagnostic marker and a novel therapeutic target for skeletal disorders characterized by impaired bone formation, such as osteoporosis.
Authors
- T. Kato (ORCID: https://orcid.org/0000-0002-2692-0492)
- Philipp Kaldis
- Toshitaka Yoshii (ORCID: https://orcid.org/0000-0003-3511-9020)
- Ali Al Kaissi (ORCID: https://orcid.org/0000-0001-5439-3346)
- Yuri Miyakoshi
- Daiyang Yu
- Tomoyuki Tanaka
- Shingo Sato
- Hiroyuki Inose
- Hiroki Ochi
Institutions
- Tokyo Medical and Dental University (JP)
- Lund University (SE)
- Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics (RU)
- Dokkyo Medical University Saitama Medical Center (JP)
- National Rehabilitation Center for Persons with Disabilities (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1016/j.jot.2025.10.010
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00